PathPlus™ Neuro Antibodies

PathPlus™ Neuro Antibodies

The LSBio PathPlus™ Neuro Antibodies represent the highest quality reagents available for research pathology applications. Over 800 antibodies were hand-selected from among thousands that were tested and identified to be the best performing reagents for immunohistochemical detection of over 400 high-value neuro targets in formalin-fixed paraffin-embedded human tissues.

This antibody is showing strong staining of astrocytes and Bergmann gliain normal human brain cerebellum.

ADGRG7 (GPR128, Adhesion G protein-coupled receptor G7) is a membrane-bound orphan receptor involved in cellular adhesion, migration, and cell-to-cell and cell-to-matrix interactions. The extracellular region of adhesion GPCRs can be exceptionally long and contain a variety of structural domains that are known for their ability to facilitate cell and matrix interactions. ADGRG7 has been suggested to have a role in intestinal absorption and musculoskeletal disorders, as well as osteochondral ossification. ADGRG7 has been shown to be modulated by ER-alpha and the Sp1 complex. LSBio’s in-house Northern blots indicated expression in liver, small intestine, and colon, and low expression in thymus, spinal cord, putamen, and medulla.

This antibody is showing strong specific staining in Alzheimer’s diseased
brain astrocytes. 

GALR3 is one of three G protein-coupled receptors for the bioactive neuropeptide galanin that modulates a variety of physiologic processes including cognition, memory, pain processing, hormone secretion, and feeding behavior. Antibody LS-A205 demonstrated strong positive staining within neurons of a variety of brain regions, as well as peripheral tissues. 

Within neurodegenerative diseases, studies at LSBio demonstrated positive staining with this antibody within senile plaques and neurofibrillary tangles in Alzheimer’s Disease.