anti-CD3 epsilon antibody [CD3-12]
About this Product
- SKU:
- ARG22819
- Additional Names:
- T-cell surface antigen T3/Leu-4 epsilon chain; T3E; TCRE; T-cell surface glycoprotein CD3 epsilon chain; IMD18; CD antigen CD3e
- Application:
- Flow Cytometry, IHC-Frozen, IHC-Paraffin, Immunocytochemistry, Immunofluorescence, Western Blot
- Buffer:
- PBS and 0.09% Sodium azide
- CE/IVD:
- RUO
- Clone:
- CD3-12
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- CD3 subunit complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins superfamily encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation.
- Host:
- Rat
- Isotype:
- IgG1
- Purification:
- Protein G Purified
- Reactivities:
- Amphibian, Avian, Bovine, Canine, Feline, Horse, Human, Mouse, Non-human Primate, Porcine, Rabbit
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- Arigo Biolaboratories
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:ARG22819.html
