anti-ERK1 + ERK2 phospho (Thr202 / Tyr204) antibody
Product Sizes
50 ul
ARG52277-50UL
100 ul
ARG52277-100UL
About this Product
- SKU:
- ARG52277
- Additional Names:
- MAPK 2; MAPK 1; MAP kinase 2; ERK-2; p41; ERK; MAP kinase 1; PRKM2; PRKM1; EC 2.7.11.24; MAPK2; p40; Extracellular signal-regulated kinase 2; p38; Mitogen-activated protein kinase 2; Mitogen-activated protein kinase 1; ERK2; MAP kinase isoform p42; p42-MAPK; P42MAPK; p41mapk; ERT1
- Application:
- Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
- Buffer:
- PBS (pH 7.4), 150 mM NaCl, 50% Glycerol, and 0.02% Sodium Azide.
- CE/IVD:
- RUO
- Clonality:
- Polyclonal
- Extra Details:
- ERK1 is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008]ERK2 is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]
- Host:
- Rabbit
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Amphibian, Avian, Bovine, Canine, Fish, Human, Mouse, Non-human Primate, Rat
- Shipping Conditions:
- Blue Ice
- Specificity:
- Specific for the ~42k - 44k ERK/MAPK phosphorylated at Thr202 and Tyr204 at p44 (ERK1), and Thr185 and Tyr187 at p42 (ERK2). Immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide. The immunolabeling is completely eliminated by L Lambda-phosphatase.
- Storage Conditions:
- -20[o]C
- Supplier:
- Arigo Biolaboratories
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:ARG52277.html
