HMGB1
Learn more about the roles of HMGB1 and how Arigo Biolaboratories can aid your research.
HMGB1 is a multifunctional protein with various roles in different cellular compartments. It is associated with various pathogenesis such as cancers, neurodegenerative disorders, and multiple inflammatory diseases. As it is a therapeutic target for a wide range of diseases, this protein has received high interest from many researchers.
Roles of the HMGB1 protein
In the nucleus - HMGB1 acts as a DNA-binding protein for:
- Gene Transcription
- Gene Regulation
- DNA repair
In the cytosol, HMGB1 induces autophagy by interacting with Beclin-1 which results in its dissociation from Bcl2 and the subsequent induction of autophagy.
Arigo's related HMGB1 products:
| Stimulation: | HMGB1 protein (ARG70220) |
| Neutralization: | HMGB1 Neutralizing antibody [SQab20175] (ARG66714) |
| Detection: | HMGB1 antibody [SQab1711] (ARG65863) |
| Quantification: | Human HMGB1 ELISA Kit (ARG81185) Mouse/Rat HMGB1 ELISA Kit (ARG81310) Serum HMGB1 ELISA Kit (ARG81351) |
Take a look at the diagram below to see many of the interactions of HMGB1 in various biological processes.
