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Proteins and Peptides

Alpha Synuclein N-Terminal Acetylated Monomers (Type 1)

Product Sizes
100 ug
SPR-331-100UG
2 x 100 ug
SPR-331-2X100UG
5 x 100 ug
SPR-331-5X100UG
About this Product
SKU:
SPR-331
Additional Names:
N-acetylated Alpha synuclein monomer, N-terminal acetylated Alpha-synuclein monomer, Alpha synuclein protein monomer, Alpha synuclein monomer, Alpha-synuclein protein, Non-A beta component of AD amyloid protein, Non-A4 component of amyloid precursor protein, NACP protein, SNCA protein, NACP protein, PARK1 protein, Alpha synuclein monomers, SYN protein, Parkinson's disease familial 1 Protein, N-terminal Ac-A Alphasyn
Application:
Cell-based/Functional Assay, SDS-PAGE, Western Blot
CE/IVD:
RUO
Concentration:
2 mg/ml
Extra Details:
Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6). Alpha synuclein purified from both normal and pathological brain tissue is N-acetylated (7) and this post-translational modification affects affect alpha-synuclein stability and toxicity (8).
Immunogen:
Alpha Synuclein N-Terminal Acetylated
Molecular Weight:
~14.46kDa
Purity:
>95%
Purification:
Ion Exchange
Shipping Conditions:
Dry Ice
Storage Conditions:
-70[o]C
Supplier:
StressMarq Biosciences
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
Western Blot analysis of Human N-Terminal Acetylated Alpha Synuclein Monomer (SPR-331). Lane 1: MW ladder. Lane 2: 2 ug SPR-331. Lane 3: 4 ug SPR-331.
Thioflavin T assay for N-terminal acetylated alpha synuclein monomers (SPR-331) and pre-formed fibrils (PFFs) (SPR-332). Increased fluorescence, indicative of beta-sheet formation, was seen when 50 ug N-acetylated monomer and 5 ug N-acetylated fibril were combined, compared to monomer or fibril alone.