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Proteins and Peptides

Tau-352 (fetal 0N3R) Wild-Type Monomers

Product Sizes
100 ug
SPR-490-100UG
2 x 100 ug
SPR-490-2X100UG
5 x 100 ug
SPR-490-5X100UG
500 ug
SPR-490-500UG
2 x 500 ug
SPR-490-2X500UG
About this Product
SKU:
SPR-490
Additional Names:
Tau aggregate, Tau protein, microtubule-associated protein Tau, MAPT, MAP, microtubule-associated protein, Truncated Tau Protein Aggregate, Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle Protein, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 2, tubulin-associated unit, 95-amino acid Tau protein fragment, Truncated Tau
Application:
Cell-based/Functional Assay, SDS-PAGE, Western Blot
CE/IVD:
RUO
Extra Details:
Alzheimer's Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing paired helical filaments (PHFs). Brain-specific tau isoforms vary in the number of N-terminal inserts and C- terminal repeat domains due to alternative splicing of exons; only the shortest isoform of tau, 0N3R, is expressed in the fetal brain during neurogenesis (2). Three-repeat (3R) isoforms have been shown to be more prone than four-repeat (4R) isoforms to form oligomers in vitro (3). The B Beta-sheet core of Tau 0N3R fibrilized using heparin differs from all other tau fibril structures known to date (4).
Immunogen:
Tau-352 (fetal 0N3R)
Molecular Weight:
37 kDa
Purity:
>95%
Purification:
Ion Exchange
Sequence:
MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Shipping Conditions:
Dry Ice
Storage Conditions:
-70[o]C
Supplier:
StressMarq Biosciences
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
Tris-glycine SDS-PAGE (12%) of Fetal Tau 0N3R monomers. MW ladder = Precision Plus Protein All Blue pre-stained standards.
Fibril formation activity of Fetal Tau 0N3R monomers in ThT seeding assay. Monomers readily form fibrils upon the addition of heparin or when seeded by 0N3R pre-formed fibrils. DTT was added to each well to control disulfide bonding during fibril formation.