Tau-441 (2N4R) Wild-Type Pre-formed Fibrils (Baculovirus/Sf9)
Product Sizes
100 ug
SPR-498-100UG
2 x 100 ug
SPR-498-2X100UG
5 x 100 ug
SPR-498-5X100UG
About this Product
- SKU:
- SPR-498
- Additional Names:
- MAPT, intracellular neurofibrillary tangles, NFTs, paired helical filaments, PHFs, 2N4R
- Application:
- Cell-based/Functional Assay, SDS-PAGE, Western Blot
- Extra Details:
- Brain-specific tau isoforms vary in the number of N-terminal inserts and C- terminal repeat domains due to alternative splicing of exons; the 2N4R isoform of tau is expressed in adult brain yet is absent from the fetal brain (1). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as Alzheimer's Disease (AD) are characterized by neurofibrillary tangles containing hyper-phosphorylated tau fibrils (2). Hyper-phosphorylated tau can be generated via expression in the Sf9/Baculovirus system, with up to 20 sites confirmed by mass spectrometry and Western Blots with phospho-specific antibodies(3). Sf9/Baculovirus-expressed Tau 2N4R Pre-Formed Fibrils are generated without heparin.
- Molecular Weight:
- 45.84 kDa
- Purity:
- >95%
- Purification:
- Ion Exchange
- Sequence:
- MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -70[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/proteins/tau-441-(2n4r)-wild-type-pre-formed-fibrils-(baculovirus/sf9)-spr-498/
![](https://www.stressmarq.com/wp-content/uploads/SPR-498_Tau-441-2N4R-Wild-Type-Pre-formed-Fibrils-Baculovirus-Sf9-Protein-TEM-1.png?width=200)
![](https://www.stressmarq.com/wp-content/uploads/SPR-498_Tau-441-2N4R-Wild-Type-Pre-formed-Fibrils-Baculovirus-Sf9-Protein-SDS-PAGE-1.png?width=200)
![](https://www.stressmarq.com/wp-content/uploads/SPR-498_Tau-441-2N4R-Wild-Type-Pre-formed-Fibrils-Baculovirus-Sf9-Protein-Mass-Spec-Table-1.png?width=200)
![](https://www.stressmarq.com/wp-content/uploads/SPR-498_Tau-441-2N4R-Wild-Type-Pre-formed-Fibrils-Baculovirus-Sf9-Protein-TEM-2.png?width=200)
![](https://www.stressmarq.com/wp-content/uploads/SPR-498_Tau-441-2N4R-Wild-Type-Pre-formed-Fibrils-Baculovirus-Sf9-Protein-TEM-1.png?width=850)
![](https://www.stressmarq.com/wp-content/uploads/SPR-498_Tau-441-2N4R-Wild-Type-Pre-formed-Fibrils-Baculovirus-Sf9-Protein-SDS-PAGE-1.png?width=850)
![](https://www.stressmarq.com/wp-content/uploads/SPR-498_Tau-441-2N4R-Wild-Type-Pre-formed-Fibrils-Baculovirus-Sf9-Protein-Mass-Spec-Table-1.png?width=850)
![](https://www.stressmarq.com/wp-content/uploads/SPR-498_Tau-441-2N4R-Wild-Type-Pre-formed-Fibrils-Baculovirus-Sf9-Protein-TEM-2.png?width=850)