Focus Biomolecules
Focus Biomolecules was founded by former members of globally recognised BIOMOL. From their industry experience they set out to refine the practices of small molecule based life sciences companies and eliminate the challenges too often found by customers.
With more than 24 years in the industry, they offer advanced, high quality reagents and a fresh, customer oriented experience.
Essential Biochemicals for Bioprocessing
Focus Biomolecules offer a broad portfolio of cutting-edge biochemicals with specific utility in bio-processing. Their bioprocessing agents will allow you control cell selection, growth, and function which will maximize protein expression, yield, glycosylation, integrity and minimize degredation, both upstream and downstream. Key product groups include:
Antibiotics & Antifungals | Cell cycle modulators | Ionophores |
|---|---|---|
Cofactors & Coenzymes | Glycosylation inhibitors | Selection & Amplification reagents |
Apoptosis & Autophagy Modulators | Protease inhibitors | Differentiation agents |
Cell growth modulators | Protein expression modulators | Stem Cell Effectors |
These products can be used to establish conditions during early stage assessment and upstream process development, to ensure optimization at every step. These include chemically defined medium design, feed/supplement selection, expression host selection, lead candidate production, process optimization, scaleup and validation.
Below is just a selection of our bioprocessing chemicals. You won't see these listed with other bioprocessing suppliers, because these are on the cutting-edge for controlling protein titer, post-translational modification, and other critical parameters. Ask us for our full product listing, which includes our comprehensive offering of bioprocessing products along with literature references and other useful information.
Product Name | Mechanism | Bioprocessing Effect | Category |
|---|---|---|---|
Antioxidant (ROS scavenger) | Increases recombinant protein production: Reduces glycation and formation of acidic charge variants | Protein production/ titre | |
Autophagy inhibitor (Vacuolar H+ -ATPase inhibitor) | Increases recombinant protein expression in cells | Protein production/ titre | |
Promotes proliferation (EP4 receptor activator) | Increases cell specific productivity | Protein production/ titre | |
Cell cycle arrest (DNA polymerase inhibitor) | Enhances transfection efficiency | Protein production/ titre | |
Cofactor (Essential) | Essential for many metabolism pathways | Cell growth and function | |
| 7-alpha Hydroxy-c\ holesterol | Building block (Essential) | Improved cell function results in higher protein expression levels in some cell cycles | Cell growth and function |
| Mycophenolicacid | Fucosylation modulator | Retention of essential post-translational modification on therapeutic protein | Therapeutic protein integrity |
| Trichostatin A | HDAC inhibitor (Reduces epi- genetic transcriptional repression) | Increases recombinant protein expression | Protein production/ titre |
| Brefeldin A | Intracellular transport inhibitor | Modulates protein titre and integrity | Scaleup and analysis |
| Chloroquine phosphate | Improves transfection; increases cell specific productivity; fine tunes glycosylation | Modulates protein titre and integrity | Scaleup and analysis |
DNA Damage and Repair
Mitochondrial Research
Stem Cells
Differentiation
Stem Cells
Survival
Stem Cells Expansion and Maintenance